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Temporary side effects may include mild nausea, bloating, or in very rare instances, a skin rash if unregulated products are used
The key anti-inflammatory metabolite itaconate, synthesized via IRG1, not only inhibits TET2-mediated DNA demethylation to alleviate bone destruction in rheumatoid arthritis (137), but also can be delivered locally through functionalized implants to suppress M1 polarization and promote vascular endothelial repair (138)
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doi:10.12991/201014455 Pickart L, Vasquez-Soltero JM, Margolina A
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